• 2.0 M Solution in Thf/ Lithium Diisopropylamide / Lda  CAS NO.4111-54-0
  • 2.0 M Solution in Thf/ Lithium Diisopropylamide / Lda  CAS NO.4111-54-0

2.0 M Solution In Thf/ Lithium Diisopropylamide / Lda CAS NO.4111-54-0

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Details

Property Details
Chemical Name Lithium Diisopropylamide
CAS Number 4111-54-0
Molecular Formula                    C6H14LiN
Molecular Weight 107.12 g/mol
Appearance Colorless solution (typically in THF/heptane)
Concentration 1.0-2.0 M in THF/hexanes
Reactivity Pyrophoric, moisture-sensitive, reacts violently with water/air                                                              
Applications Enolate formation, organic synthesis, pharmaceuticals
Storage Store under inert gas (N2/Ar) at 2-8°C in flame-proof containers

Lithium diisopropylamide (LDA) is a highly reactive, non-nucleophilic strong base widely used in organic synthesis for deprotonation reactions. It is particularly effective for generating enolates from carbonyl compounds and facilitating α-alkylation reactions. LDA is essential in pharmaceutical manufacturing, polymer chemistry, and the synthesis of fine chemicals. Its steric bulk prevents unwanted side reactions, making it ideal for selective deprotonation. Typically used in THF or ether solutions at low temperatures (-78°C), LDA requires careful handling under inert atmospheres due to its moisture and air sensitivity.