Chlormadinone Acetate CAS NO.302-22-7

Superiority PackingStandard packaging includes the following: 25kg/drum Other package sizes are available upon request. StorageStore in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use. Period of validity24 months ? Product Superiority ? 1.High quality

Description:

Superiority

PackingStandard packaging includes the following: 25kg/drum Other package sizes are available upon request.

StorageStore in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use.

Period of validity24 months

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Product Superiority

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1.High quality with best price

2.Well reputation

3.Factory with strong supply ability

4. Prompt shipment

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Packing & Delivery

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FAQ

1. who are we? We are based in Shandong, China, start from 2014,sell to Southern Europe(00.00%),Domestic Market(00.00%),South America(00.00%),North America(00.00%),Eastern Europe(00.00%),Africa(00.00%),Eastern Asia(00.00%). There are total about 11-50 people in our office. 2. how can we guarantee quality? Always a pre-production sample before mass production; Always final Inspection before shipment3. why should you buy from us not from other suppliers? Have a strong ability to warehousing logistics and release permit of dangerous goods export right and use right, has a strong factory as a backstop. 4. what services can we provide? Accepted Delivery Terms: FOB,CFR,CIF,EXW; Accepted Payment Currency :USD; Accepted Payment Type: T/T,L/C; Language Spoken:English,Chinese

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Details

Bioactivity

Chlormadinone acetate (Gestafortin) is a steroidal progesterone with anti-androgenic and anti-gonadotropic effects. Its half-life is approximately 34-38 hours.

Uses
Potential progestin.

Production Method
In a 2000mL three-necked flask, add 100g of self-prepared chlormadinone acetate and 1000mL of glacial acetic acid. While stirring, add 50g of acetic anhydride and 2g of p-toluenesulfonic acid. Slowly heat the reaction mixture and stir at 40-45℃ for 8-12 hours. After the reaction is complete, add 10mL of 30% sodium hydroxide solution to neutralize the strong acid in the reaction solution. Then concentrate under reduced pressure to recover 85-90% of the glacial acetic acid. Add 600mL of tap water to the concentrated reaction solution, cool to 10-15℃, and stir for 2-3 hours to promote crystallization. The crystals were collected by filtration, washed with water until neutral, and the filter cake was dried below 70°C to obtain 114.2 g of crude product (8R,9S,10R,13S,14S,17R)-17-acetyl-6-Chemicalbookchloro-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecano-1H-cyclopentano[a]phenanthrene-17-yl acetate, with an HPLC purity of 98.8%. The filtrate and washings were combined, and the residual solvent was recovered and disposed of to the wastewater treatment system. The crude product was decolorized and recrystallized using conventional methods with alcohol and activated carbon to obtain 97.8 g of pure product with a melting point of 208-212°C, an HPLC purity of 99.5%, and a yield of 97.8%. References: [1] Patent: CN107698645, 2018, A. Location in patent: Paragraph 0016; 0019; 0022 Storage and transportation characteristics Warehouse low temperature ventilation drying fire extinguishing agent water, dry powder, carbon dioxide, foam