Glycine Methyl Ester Hydrochloride CAS NO.5680-79-5

Uses: Glycine methyl ester hydrochloride can be used as a raw material for domestic insecticides, pyrethroids, and pharmaceuticals. Chemical Properties: This product is a white crystalline solid, decomposes at m.p. 175℃, readily soluble in water, and hygroscopic.

Uses: Glycine methyl ester hydrochloride is an important intermediate in the preparation of chrysanthemic acid and dichlorochrysanthemic acid, and also an intermediate for the fungicide iprodione. Uses: In pharmaceuticals, food, organic synthesis, etc. It can be prepared using glycine or chloroacetic acid as raw materials. Details are as follows: Glycine-based method: Dry hydrogen chloride gas is passed into anhydrous ethanol to prepare a hydrogen chloride ethanol solution. Then, glycine is added, and the mixture is heated and stirred to carry out esterification. The reaction temperature is controlled at 80-85℃. After the glycine is completely dissolved, the mixture is stirred for a few more minutes. While still hot, the reaction solution is transferred to a crystallization pot, cooled to crystallize, and filtered to obtain glycine ethyl ester hydrochloride. The reaction equation is: NH?CH?COOH + C?H?O[HCl] → NH?CH?COOC?H?·HCl. Alternatively, glycine and anhydrous ethanol can be added to a stirred reactor, heated to 60°C, and hydrogen chloride gas is introduced. Hydrogen chloride is introduced until the reactants are completely dissolved, and then continued until recrystallization is complete (using the Chemicalbook). The reaction solution is then transferred to a crystallization pot, stirred, cooled, and crystallized. The mixture is filtered, washed with anhydrous ethanol, and dried to obtain glycine ethyl ester hydrochloride. In the chloroacetic acid-based method, chloroacetic acid, hexamethylenetetramine, and anhydrous ethanol are added to a reactor. Ammonia gas is introduced at 45°C to maintain the pH at 8–8.5. The ammonia gas introduction rate is controlled to maintain the reaction temperature between 40–65°C. After the ammonia gas is introduced, the reaction is maintained at 65°C for 1 hour, then cooled to 30°C, and a hydrogen chloride-anhydrous ethanol solution is added dropwise. After the addition is complete, react at 70℃ for 2 hours, then filter while hot at 62-65℃ to separate ammonium chloride crystals. Place the filtrate in a crystallization pot, cool to 10℃, and crystallize while stirring. Filter and dry the crystals to obtain glycine ethyl ester hydrochloride. The reaction equation is: ClCH2COOH + NH3 [ethanol] → NH2CH2COOH [C2H5OH] → [HCl]NH2CH2COOH·HCl. Using methanol instead of ethanol yields glycine methyl ester hydrochloride. The reaction equation is: NH2CH2COOH + CH3OH [HCl] → NH2CH2COOCH3·HCl