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Flucytosine, an organic compound with the chemical formula C4H4FN3O, is an antifungal drug. It has high antibacterial activity against Cryptococcus and Candida genera, and certain antibacterial activity against chromogenic fungi and a few Aspergillus genera. However, its antibacterial effect on other fungi is poor.
Application&Function
Flucytosine is an antifungal drug, mainly used to treat various infections caused by fungi, especially Candida and Cryptococcal infections. Its mechanism of action is to effectively inhibit the growth and reproduction of fungi by interfering with the synthesis of RNA and DNA in fungal cells. This article will provide a detailed introduction to the indications, efficacy and functions, dosage and administration, side effects and precautions of fluorocytosine.
1. Indications
Fluorocytosine is mainly used to treat infections caused by fungi, such as cryptococcal meningitis and candida infections. It is often used in combination with other antifungal drugs, especially in the treatment of severe fungal infections. Fluorocytosine can also be used in the treatment of some drug-resistant fungal infections.
2. Functions and Effects
Fluorocytosine affects the nucleic acid synthesis of fungi and inhibits their growth by converting to 5-FU. Its powerful antifungal effect makes it an important choice for the treatment of some refractory fungal infections. Furthermore, due to the high selectivity of fluorocytosine and its relatively small impact on human cells, it is relatively safe at an appropriate dose.
3. Dosage and Administration
Fluorocytosine is usually administered orally or by intravenous injection. The commonly used dosage for adults is 25-37.5 milligrams per kilogram of body weight, taken 3-4 times a day. The duration of medication depends on the infection. It is particularly important to note that doctors will adjust the dosage based on the patients liver and kidney functions and other conditions to avoid adverse reactions caused by improper medication.
4. Side Effects
The side effects of flucytosine may include gastrointestinal discomfort, bone marrow suppression, abnormal liver function, etc. Some patients may experience allergic reactions, such as rashes and itching. In addition, long-term use may lead to fungal resistance, so it is necessary to monitor the patients response regularly and adjust the treatment plan in a timely manner.
